Brovnol D tablets (niclosamide, oxibendazole, levamisole hydrochloride) 20 tablets
Anthelmintic, antiparasitic
Storage
1 tablet (0.5 g) contains:

niclosamide - 230 mg

Oxibendazole - 30 mg

levamisole hydrochloride - 40 mg

Excipients: lactose, glucose, potato starch, orisil, sodium croscarmellose, calcium stearate.

Description
Tablets are light yellow, oblong, with a faint specific odor.

Pharmacological properties
The action of the drug is due to the complex of pharmacological properties of its active substances, providing a wide spectrum of antiparasitic action against cestodes and nematodes.

Niclosamide is a synthetic derivative of salicylic acid, active against intestinal cestodes. Disrupts oxidative phosphorylation processes, which interrupts anaerobic glycolysis in the body of tapeworms, as a result of which the latter lose mobility, die and are digested in the intestine.

When taken orally, it acts in the cavities of the small and large intestines. It is not metabolized. The half-life is 2.5-5 hours. It is excreted in feces.

Oxibendazole is a benzimidazole derivative, has a broad spectrum of action against nematodes and cestodes. It blocks fumarate reductase and disrupts energy metabolism in helminths, causing paralysis and death of parasites at all stages of development within a few hours after application.

Oxibendazole is broken down in the liver to metabolites, does not have anthelmintic activity.

Levamisole hydrochloride is a synthetic derivative of imidazothiazole with a narrow spectrum of action, an immunostimulant. The anthelmintic effect is due to the blockade of the enzyme succinate dehydrogenase, which causes a disruption of energy metabolism in parasites and depolarization of the membranes of helminth muscle cells. Only some nematodes are sensitive to levamisole.

It is well absorbed when taken orally, the maximum concentration in the blood is achieved after 1.5-2 hours. It is metabolized in the liver with the formation of inactive metabolites. It is excreted mainly by the kidneys (95%), partly with feces unchanged. The half-life is 3-4 hours.

Indication
Treatment and prevention of helminthiasis in mixed infestations caused by:

dogs, cats: larvae and adult helminths of the gastrointestinal tract - ancylostomiasis (Ancylostoma caninum), dipylidiosis (Dipylidium caninum), diphyllobothriasis (Diphyllobothrium latum, D. minus), toxocariasis (Toxocara canis, T. cati), toxascariasis Tricharis vulpis, T. nutpia), taeniasis (Taenia hydatigena, T. multiceps);
ornamental birds: ascariasis (Ascaridia galli, A. dissimilis, A. columbae), capillariasis (Capillaria anseris, C. anatis, S. contorta), syngamosis (Syngamus trachea), streptocariasis (Streptocara crassicauda), hymenolepiasis (Hymenolepis, Hymenolepis, paracompressa, Fimbriaria fasciolaris), tetramerosis (Tetrameres fissispina).
Contraindications
Do not use in animals with intestinal atony.

Do not use poultry, the meat of which is consumed by people.

Method of administration and dosage
For dogs and cats, the drug is given once in crushed form with food or forcibly on the root of the tongue.

Animal weight, kg Dose of the drug, tablets.
up to 2 1/4
2-5 1/2
5-10 one
10-20 2
20-30 3
30-40 4
40-50 5
Ornamental birds are given mixed with feed:

Chicken family - 1 tablet per 10 kg of body weight, course - 3 days;
Geese and duck family - 1 tablet per 2 kg of body weight, course - 2 days.
Reservation
Do not exceed the recommended doses. In some animals with severe invasion, complications are possible due to intoxication due to digestion of dead helminths: urticaria and itching in the rectum, anxiety, diarrhea, vomiting. These symptoms quickly pass without special treatment.

Storage conditions
In a dry place, protected from light and inaccessible to children at a temperature of up to +25 ° C.

Expiration date
3 years.