CifIodex (ciprofloxacin, dexamethasone) eye and ear drops
Treatment of dogs, cats, small, exotic and decorative animals with acute and chronic inflammation of the eyes and ears caused by bacterial, chemical or traumatic effects - conjunctivitis, blepharitis, keratitis, keratoconjunctivitis, iritis, iridocyclitis, ulcers and erosions of the cornea, eye diseases after injuries or the ingress of foreign bodies or aggressive compounds in the postoperative and preoperative periods, as well as otitis, otorrhea, in particular, caused by outside interference.

Before using Cifiodex drops, you must carefully read the instructions and consult a veterinarian.

Suspension for external use (eye and ear drops) 1 ml contains:

ciprofloxacin 4.5 mg
dexamethasone 1 mg
Pharmacological properties:

A combination chemotherapeutic agent that combines a broad-spectrum antibiotic from the fluoroquinolone group (ciprofloxacin) and a GCS (dexamethasone), which has antibacterial, anti-inflammatory, anti-allergic and desensitizing properties.

Ciprofloxacin acts bactericidally, inhibiting DNA gyrase and suppressing the synthesis of bacterial DNA. Active against gram-negative microorganisms in the dormant and dividing stages – Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Vibrio spp., Campylobacter spp., Hafnia spp., Providencia stuartii, Haemophilus spp., Pasteurella multocida, Pseudomonas spp., Gardnerella spp., Neisseria spp., Moraxella catarrhalis, Acinetobacter spp., Brucella spp., gram-positive microorganisms in the dividing stage – Staphylococcus spp., Streptococcus pyogenes, Streptococcus agalactiae, Соrynebacterium diphtheriae, Listeria monocytogenes and other pathogens – Chlamydia spp., Mycoplasma spp., Mycobacterium spp-

It is well absorbed, after 60 minutes its concentration in the tear fluid is 4.98 μg/ml, and in the fluid of the anterior chamber of the eye - 2.59 μg/ml. The half-life from the anterior chamber of the eye is 2 hours. When instilled into the eyes, the concentration of ciprofloxacin in the blood does not exceed 2.5 ng/ml, when instilled into the ears, the maximum concentration in the blood is achieved after 15-90 minutes and is approximately 0.1% of the concentration of ciprofloxacin taken orally at a dose of 250 mg.

Dexamethasone is a synthetic fluorinated GCS with anti-inflammatory, antiallergic and antiproliferative action. Reduces capillary permeability and proliferation, local exudation, cell infiltration, phagocytic activity, collagen deposition and fibroblast activity, suppresses scar tissue formation and inflammation symptoms. The anti-inflammatory effect after instillation lasts for 4-8 hours. With local application, systemic absorption is low. After instillation into the eyes, dexamethasone penetrates well into the corneal epithelium, conjunctival cells and into the fluid of the anterior chamber of the eye, its maximum concentration of 30 ng/ml is achieved after 2 hours, the half-life is 3 hours. When applied to the ears, the maximum concentration in the blood is achieved after 15-90 minutes and is approximately 14% of the concentration of dexamethasone taken orally at a dose of 5 mg. Dosage and administration:

The drug is instilled into the conjunctival sac 1-2 drops 2-4 times a day (in difficult cases, 1-2 drops are instilled for 1-2 days every 2-3 hours) or into the ear canal 1-4 drops (depending on the animal's weight) 2-3 times a day.

In the presence of significant purulent or mucopurulent discharge, preliminary hygienic treatment of the eyes or ears is carried out: 3-4 drops are instilled and the discharge is removed with a sterile gauze swab, after which 1-2 drops of the drug are instilled. The course of treatment until complete recovery is 5-10 days.

Precautions:

When instilled into the eyes, local irritation, itching, lacrimation are sometimes possible, which quickly pass, allergic reactions are rare, with prolonged use - the development of secondary glaucoma, steroid cataract. Use with caution in animals for up to 7 days.

Contraindications:

Do not administer to animals with hypersensitivity to the active ingredients of the drug.

Packaging:

Polymer bottles with a dropper of 10 ml in an individual cardboard box.

Storage:

In a dry place, protected from light and inaccessible to children, at a temperature of +10 to +25 ° C.

After opening the bottle, use the drug within 30 days.