COMPOSITION
1 ml of the drug contains the active substance:
doramectin - 10.0 mg.
Ethylolate, butylhydroxyanizonol, benzoyl alcohol, cottonseed oil.

PHARMACOLOGICAL PROPERTIES
ATC vet QP54, endexides (QP54A03, doramectin)
Domictin is a macrocyclic lactone, a semi-synthetic form of avermectin. Doramectin exhibits a large number of systemic nematodocidal, insecticidal and acaricidal action, larvocidal and ovicidal. Modulates the activity of chlorine ions in the nervous system and muscles of nematodes and arthropods. By binding to special receptors, they increase the permeability of synaptic membranes for chlorine ions, which leads to blockade of the activity of nerve and muscle cells of nematodes and arthropods, which leads to paralysis and death of parasites. In mammals, these receptors are localized only in the central nervous system, and doramectin does not pass through the blood-brain barrier and is therefore safe for mammals in recommended doses.
The drug in the recommended doses does not cause mutagenic, teratogenic and embryotoxic interference.
DORAMAX is easily absorbed from the injection site, has high efficiency and does not have a negative effect on the animal's body. Pharmacokinetic properties of doramectin ensure preservation of therapeutic concentrations in the blood of animals and protect against reinvasion for a long time. The prolonged action lasts twice as long as other medicines containing ivermectins.

APPLICATIONS
Treatment and prevention of diseases caused by nematodes and ectoparasites in cattle, sheep, pigs, cats, dogs, and rabbits:

Cats and dogs:
fleas: Ctenocephalides;
lice: Linognathides spp., Heamatopinus canis, Trichodectes canis, Felicola subrostratus;
ticks: Demodex canis, Demodex katoi, D.felis, Otodectes cynotis, Dermacentor spp., Rhipicephalus spp., Ixodes spp., Sarcoptes canis, Neotrombicula automnalis, Cheyletiella.

DOSAGE
Cattle: 1 ml per 50 kilograms of body weight (equivalent to 200 mcg / kg), once in the neck area.
Sheep: 1 ml of the drug per 50 kilograms of body weight (equivalent to 200 mcg / kg), once, intravenously; for diseases caused by Psoroptes ovis (lice scabies) and Nematodirus battus (ripe mature stage) - 1 ml of the drug per 33 kilograms of body weight (equivalent to 30 

0 μg / kg), internally.
Pigs: 1 ml per 33 kilograms of body weight or 0.3 ml / 10 kilograms of body weight (equivalent to 300 mcg / kg), intrathecally.
Increased body weight to 16 kilograms and less (table):

Body weight of piglets, kg

Dose, mL

 4

0.1

5-7

0.2

8-10

0.3

11-13

0.4

14-16

0.5

Cats and dogs:
 The first method is in a mixture with an oily solution of vitamins:
For cats: 1.0 ml of medicine + 1.0 ml of solution of group B vitamins for every 10 kilograms of the animal's weight in the thigh area. That is, 0.2 ml of the mixture of solutions per 1 kilogram of the cat's weight.
For dogs: 1.0 ml of medicine + 1.0 ml of solution of group B vitamins for every 16 kilograms of the animal's weight in the thigh area. That is, 0.125 ml of the mixture of solutions per 1 kilogram of the dog's weight.
Secondly, the pure drug:
For cats: 1.0 ml of the medicine for every 10 kilograms of the animal's weight once.
Dogs: 1.0 ml of medicine for every 16 kilograms of the animal's weight once.
Rabbits: 1.0 ml of the drug per 10 kilograms of weight, i.e. 0.1 ml of the drug for each kilogram of body weight.
Prevention is carried out twice a year in the autumn-winter period of the year with the correct content of animals. In addition, vitamin preparations are administered in solutions.

ANTI-WICKING
Increased sensitivity to medication components.
Females should not be lactated if the milk is used for human consumption!
It is not possible to use medicine against ladybugs and cowpox 60 days before departure!

WARNINGS
Animals for meat are allowed after the last administration of drugs: cattle and sheep - after 35 days, pigs - after 28 days.
By the last deadline, the meat is disposed of or fed to unproductive animals, depending on whether the doctor prescribed it with veterinary medicine.
FORM OF ISSUE
Vials made of neutral glass of the brands НС-1, НС-2, USP-1, closed with rubber stoppers under an aluminum break-in, 10 each; 20; 50; 100; 200 ml. Secondary packaging - cardboard box.
STORAGE
Dry, protected from light place, at a temperature of 5 to 25 Os. Separated from food products and food products that are inaccessible to children and animals.
EXPIRY PERIOD
3 years.