Composition
One dose (1 ml) of the vaccine contains:

rabies virus, strain Vnukovo-32-Bio SAD — min. 1 MO.
Excipients:

aluminum hydroxide (adjuvant) — 1.5-3 mg,
thiomersal (preservative) — 0.085-0.115 mg,
MEM nutrient medium — up to 1 ml.
Pharmacological properties
Immunobiological properties

After entering the body of the vaccinated animal, the antigens contained in the vaccine are recognized as foreign elements, and a number of protective mechanisms are activated in the body (macrophages, opsonins, interleukins, β-lymphocytes, etc.), as a result of which antibodies specific to the antigenic determinants contained in the vaccine begin to form. These mechanisms should protect against the subsequent development of infection after infection.

The vaccine is used in animals aged 12 weeks and older, with revaccination after 1 year. Immunity develops 14 days after the primary vaccination, and persistent immunity is formed after revaccination and lasts for 2 years. Animals vaccinated before a certain period are revaccinated at intervals of at least 14 days so that revaccination is done at the age of at least 12 weeks. To maintain immunity, revaccination of animals is recommended in accordance with national requirements.

Indications for use
For active vaccination of cattle, horses, pigs, sheep, goats, dogs, cats, fur animals against rabies, starting from the age of 12 weeks.

Contraindications
Systemic hyperthermic diseases. Do not vaccinate injured animals or animals that have been in contact with individuals sick with rabies. Animals that have attacked people are vaccinated only after they have been kept in quarantine.

Warning
Shake the contents of the vial well before use and warm it to room temperature (15-25)°C. Only clinically healthy animals with a good body condition can be vaccinated. Deworming should be carried out at least 10 days before vaccination. Vaccinated animals should not be trained or subjected to physical exertion for one week after vaccination.

Withdrawal period: zero days.

Special warnings for persons and service personnel who use VIP

Follow the rules for working with veterinary drugs.

Special safety measures when handling unused VIP, methods for its neutralization and disposal

Unused and expired product or used empty vials should be disposed of by boiling for 30 minutes.

Use during pregnancy and lactation
Do not vaccinate animals during the last 2 weeks of pregnancy.

No studies have been conducted on the safety of using the vaccine during lactation. The decision on administering the product to animals during lactation is made directly by the veterinarian.

Interaction with other products and other types of interaction
The Biokan R vaccine can be used separately or simultaneously with other vaccines of the Biokan series:

a) as a solvent for other lyophilized vaccines (e.g. Biokan DHPPi, Biokan DP, Biokan P);

b) in combination with liquid vaccines Biokan S, Biokan B, Biokan M, Biokan L.

Method of administration and dosage
1 ml regardless of the age, weight and breed of the animal. Method of administration: subcutaneously in the area under the shoulder blades or intramuscularly in the muscles of the hind limbs.

The vaccine is used in animals aged 12 weeks and older, revaccination is carried out after 1 year. Immunity develops 14 days after the primary vaccination, and persistent immunity is formed after revaccination and lasts for 2 years. Animals vaccinated before the specified period are revaccinated at intervals of at least 14 days so that the revaccination is done at the age of at least 12 weeks. To maintain immunity, it is recommended to revaccinate animals in accordance with national requirements.

Side effects
In rare cases, fever and temporary anorexia may occur after vaccination. In exceptional cases, allergic reactions may occur. The vaccine should be used immediately after dissolution.

Storage conditions
Store in a dry, dark place at a temperature of 2°C to 8°C. Do not freeze!

Shelf life
2 years. Use the vaccine from an opened vial within 10 hours.

Release form
Suspension.

Vials with the vaccine are placed in plastic boxes with cells. Each box contains an approved insert card.

Category of dispensing
By prescription.