Description

Light yellow liquid.

Pharmacological properties

A combined anthelmintic drug with a broad spectrum of action on round and tapeworms of all stages of development.

Praziquantel is a synthetic compound, a derivative of quinoline, which disrupts the permeability of helminth cell membranes for calcium ions, which leads to inhibition of glucose metabolism, destruction of cell membranes in parasites, their paralysis and death. It is well absorbed in the gastrointestinal tract and reaches its maximum concentration in the blood plasma after 1-3 hours, the bioavailability of praziquantel is about 80%. It is metabolized in the liver with the formation of inactive metabolites, excreted from the body with urine, partly with feces. The half-life is about 1.5 hours.

Pyrantel pamoate is a tetrahydropyrimidine derivative, active against nematodes of all forms of development, blocks the transmission of nerve impulses in neuromuscular synapses by depolarizing the membranes of muscle cells, thereby causing paralysis of the muscular system of nematodes. Almost not absorbed from the intestine, due to which the anthelmintic effect is prolonged. It is excreted from the body mainly unchanged (93%) with feces. Indications

Treatment and prevention of dogs and cats with nematodosis (toxocariasis, toxascariasis, uncinariasis, trichuriasis, ancylostomiasis), cestodiasis (teniasis, dipylidiosis, echinococcosis, diphyllobothriasis, mesocestoidosis) and mixed nematodosis-cestodosis invasions caused by Toxocara canis, Toxocara mistax, Toxascaris leonina, Uncinaria spp., Trichuris vulpis, Ancylostoma spp., Echinococcus granulosus, Alveococus multilocularis, Mesocestoides lineatus, Dipylidium caninum, Diphyllobotrium latum, Multiceps multiceps, Taenia spp.

Contraindications

Do not administer to animals with hypersensitivity to the active ingredients of the drug, females in the first half of pregnancy and for two weeks after birth, puppies and kittens up to 3 weeks old, exhausted animals and animals with infectious diseases. Do not use simultaneously with piperazine and drugs that inhibit cholinesterase.

Method of administration and dosage

Shake the suspension before use, give it to animals individually, once, in the morning feeding with a small amount of food or forcefully administer to the root of the tongue using a measuring cup or a syringe without a needle. Dose - 1 ml per 3 kg of body weight, for small animals - 0.33 ml (14-15 drops) per 1 kg of body weight.

In case of severe infestation, deworming is repeated after 10 days.

Preventive deworming is carried out quarterly, as well as 12-14 days before vaccination.

It is not necessary to use a fasting diet or laxatives before administering the drug.

Warnings

In some animals with severe infestation due to intoxication, urticaria, itching in the anus, anxiety, diarrhea, and sometimes vomiting may occur. These symptoms disappear without special treatment.

Packaging

Polymer bottles of 5, 10 ml (1 pc. in a cardboard box complete with a pipette).

Storage conditions

In a dry, dark place inaccessible to children, separate from food and feed at a temperature of +4 to +25 °C.

After opening the bottle, store the drug in the refrigerator and use within 30 days.

Shelf life

2 years.