Description
Viscous solution from yellow to brown color.

Composition
1 ml of the drug contains the active substance doxycycline hydrochloride - 200 mg.

Excipients: propylene glycol, magnesium chloride, lidocaine, water for injection.

Pharmacological properties
Doxycycline, which is part of the drug, belongs to semi-synthetic antibiotics of the tetracycline group with a broad spectrum of action, is active against gram-positive and gram-negative microorganisms, incl. Escherichia coli., Yersinia enterocolitica, Bordettela pertussis, Shigella spp., Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Klebsiella pneumoniae, Leptospira spp., Clostridium spp., Listeria monocytogenes, Corynebacterium pyogenes, rhusiopathiae, Fusobacterium necroforum, Actinobacillus spp., Rickettsiae spp., Chlamydia spp, and Mycoplasma spp.

The mechanism of bacteriostatic action of doxycycline is associated with the inhibition of enzymes that catalyze the binding of aminoacetyl RNA to ribosomal acceptors, which leads to blocking the interaction of aminoacyl transfer RNA with matrix RNA and disruption of microbial cell protein synthesis.

After parenteral administration of the drug, doxycycline is well and quickly absorbed from the injection site, reaching therapeutic concentrations in 0.5-1 hour; easily penetrates most organs and tissues of the animal, is metabolized in the liver with the formation of inactive metabolites. It is excreted from the body mainly with bile and partly with urine.

According to the degree of impact on the body, Doxycil belongs to moderately hazardous substances (hazard class 3 according to GOST 12.1.007-76), in recommended doses it is well tolerated by animals, does not have embryotoxic, teratogenic and hepatotoxic properties.

Application
Doxycycline is used to treat cattle, sheep, goats, pigs and dogs with infections caused by microorganisms sensitive to doxycycline, including colibacillosis, salmonellosis, staphylococcosis, pneumonia, hemophilia, enzootic pneumonia of pigs, erysipelas of pigs, pasteurellosis, foot rot, ehrlichiosis in dogs, keratoconjunctivitis, wound infection, arthritis, umbilical sepsis, abscesses, chlamydia and other diseases of bacterial and mycoplasmal etiology.

Dosage
Doxycycline is administered to animals once in doses:

cattle, sheep and goats - 1.0 ml per 10 kg of animal weight (which corresponds to 20 mg of doxycycline per 1 kg of animal body weight);
pigs - 0.5 ml per 10 kg of animal weight (equivalent to 10 mg of doxycycline per 1 kg of animal body weight);
dogs - 0.25 ml per 10 kg of animal weight (equivalent to 5 mg of doxycycline per 1 kg of animal body weight).
If necessary, the drug is administered again 48 hours after the first injection.

Due to the possible pain reaction when administering the drug in a volume exceeding 2.5 ml for piglets and lambs, 5 ml for adult pigs, sheep and calves, and 10 ml for cattle, injections should be administered in several places.

Treatment of dogs with chlamydial infections should last at least 7 days.

The drug should be used with caution in calves under 12 months of age and piglets under 6 months of age due to the possibility of side effects - a pain reaction upon administration and swelling at the injection site.

Contraindications
The drug is prohibited for use in animals during pregnancy and lactation. It is prohibited to use the drug simultaneously with antibiotics of the penicillin and cephalosporin groups, as well as calcium preparations due to a possible decrease in its activity.

Side effects
When using Doxacil according to the package insert, side effects are usually not observed, with the exception of increased individual sensitivity of the animal to doxycycline, in these cases intravenous administration of calcium preparations (calcium gluconate, calcium chloride), antihistamines is indicated.

Overdose
In case of an overdose of Doxacil, the following symptoms may occur: diarrhea, vomiting, refusal to eat, impaired coordination of movement. In this case, stop using the drug and conduct symptomatic therapy.

Warnings
Slaughter of animals for meat is allowed no earlier than 21 days after the last use of Doxacil. The meat of animals forced to be killed before the expiration of the specified period may be used as feed for fur animals.

Storage
The medicinal product is stored in the manufacturer's sealed packaging, separately from food products and feed, in a dry, dark place inaccessible to children at a temperature of 5ºС to 25ºС.

Production form
Sterile solution, packaged in 10, 50, 100 ml in hermetically sealed glass bottles, sealed with rubber stoppers and rolled up with aluminum caps.

Shelf life:
Doxycil - 2 years from the date of manufacture. After opening the bottle, store the medicinal product in the refrigerator, use within 28 days.