Description
Tablets are round, biconvex, yellowish-white in color. Warehouse
The skin tablet contains an active ingredient with a dosage of 5 mg firocoxib per 1 kg of animal body weight. Other ingredients:
lactose monohydrate, microcrystalline cellulose, calcium stearate, polyvinylpyrolidone, corn starch, colostrum silicon dioxide, yeast powder. Pharmacological properties
ATCvet QМ01АН90, non-steroidal anti-inflammatory and antirheumatic agents.
FIROMAX is a non-steroidal anti-inflammatory agent based on firocoxib, which is a selective inhibitor of COX-2 (cyclooxygenase-2). The mechanism of action of firocoxib involves selective disruption of the formation of prostaglandins, which participate in the formation of the inflammatory reaction and the suppression of the proliferative and exudative phases of inflammation. It has an important effect during inflammation and has a very weak effect on the production of prostaglandins, which regulate blood flow and the integrity of the intestinal tract. It has anti-inflammatory, analgesic and antipyretic effects. The maximum concentration of firocoxib in the plasma of dogs is reached after 1.25 (±0.85) hours, bioavailability becomes 36.9 (±20.4)%. The maximum concentration of the active substance in plasma is 0.52 (± 0.22) μg/ml. The period of incubation is 7.59 (± 1.53) hours. Firocoxib is fully bound to blood proteins, metabolized in the liver and excreted from the liver via the intestinal tract. Application
To reduce inflammation and pain during treatment of dogs with osteoarthritis; as an anti-inflammatory, pain-relieving and antipyretic agent in the perioperative period (surgical interventions, orthopedic, dental and on soft tissues). Dosage
The drug is administered to dogs individually orally once with food or by mouth on the root of the tongue in a minimum therapeutic dose: 5 mg firocoxib per 1 kg of body weight per day once. Animal body weight Number of tablets of the corresponding size per use Content of firocoxib
5 – 10 kg 1 tablet 50 mg
10 – 16 kg 1 tablet 80 mg
16 – 25 kg 1 tablet 125 mg
25 – 45 kg 1 tablet 225 mg
For dogs with body weight above 45 kg of the drug can be dosed using the appropriate combination of tablets.

Sharing of tablets is not allowed.

Osteoarthritis:
The suitability of the drug for use depends on the state of the animal and is determined by the veterinarian.

Surgical instructions: To reduce pain, the drug is used 2 hours before the start of the operation. For treatment needs, the period is 3 days. Treatment of dogs after orthopedic surgery can take longer than prescribed by a veterinarian.

Contraindications

Do not use on pregnant women and pregnant animals!
Not suitable for dogs under 10 years of age and/or weighing less than 3 kg! Do not use animals with possible bleeding in the herbal channel, in case of blood dyscrasia or hemorrhagic disorders! Do not use simultaneously with other non-steroidal anti-inflammatory drugs or corticosteroids!

Cautions

Use of the drug to very small animals with suspected or confirmed liver, heart and nerve dysfunction may be an additional risk.

Do not use in dehydrating, hypovolemic or hypotensive animals due to the risk of increased nephrotoxicity.

The following is to avoid immediate use of products that are toxic to animals.

Animals with a risk of bleeding in the herbal canal, or in which increased sensitivity to non-steroidal anti-inflammatory agents has previously been detected, use the drug only under the supervision of a veterinary physician. The use of the drug should be strictly stopped if any of the following symptoms are observed: vomiting, diarrhea, hidden blood in the feces, loss of appetite, sudden loss of weight, weakness, decrease in blood or liver biochemical parameters. The preparation is stored at temperatures from 0 to 30°C.

The term of adjudication is up to 3 years.