COMPOSITION AND FORM OF RELEASE

An antibacterial drug of long action, containing in 1 ml as an active substance 150 mg of amoxicillin in the form of trihydrate and an oily filler. It is released in the form of a sterile suspension for injection of white color in 100 ml dark glass bottles, which are placed in cardboard boxes.

PHARMACOLOGICAL PROPERTIES

Amoxicillin is a semi-synthetic antibiotic from the penicillin group. It has a broad spectrum of bactericidal action against gram-positive (Actinomyces spp., Bacillus anthracis, Clostridium spp., Corynebacterium spp., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Staphylococcus spp., Streptococcus spp.) and gram-negative microorganisms (Actinobacillus spp., Bordetella bronchiseptica, E. coli, Salmonella spp., Fusobacterium spp., Haemophilus spp., Moraxella spp., Pasteurella spp., Proteus mirabilis). The drug does not act on penicillinase-producing strains of microorganisms from the genera Klebsiella and Enterobacter, as well as Pseudomonas. Amoxicillin prevents the synthesis of the bacterial cell membrane by inhibiting the enzymes transpeptidase and carboxypeptidase and causing a disruption of the osmotic balance, which leads to the death of the bacterium at the growth stage. The oily filler included in the drug gradually releases micronized amoxicillin into the blood, thereby ensuring a long-term effect of the antibiotic. When administered parenterally, amoxicillin 15% LA is well absorbed into the blood from the injection site and is quickly distributed in the body, reaching the highest concentration in muscle tissue, liver, kidneys, and gastrointestinal tract due to insignificant binding to plasma proteins (17–20%). Amoxicillin penetrates the brain and bone fluid to a small extent, except for cases when the meninges are inflamed. The maximum concentration in the blood plasma is achieved 1–2 hours after drug administration and remains at a therapeutic level for 48 hours. Amoxicillin is practically not metabolized. It is excreted from the body mainly with urine, to a lesser extent with milk and bile.

INDICATIONS

It is prescribed to cattle, sheep, goats, pigs, dogs and cats for the treatment of bacterial infections of the gastrointestinal tract (including enteritis, gastroenteritis, gastroenterocolitis), respiratory diseases (including bronchitis, bronchopneumonia, rhinitis), surgical diseases (including wounds, abscesses, joint inflammation), diseases of the genitourinary system (metritis, endometritis, cystitis, urethritis, pyelonephritis), diseases of the skin and soft tissues (including umbilical infections), as well as complications caused by microorganisms sensitive to amoxicillin. For the treatment of leptospirosis, mastitis, agalactia in pigs, actinomycosis, swine erysipelas, parainfluenza and paratyphoid fever.

 DOSAGE AND ADMINISTRATION

Amoxicillin 15% LA is administered to animals intramuscularly or subcutaneously at a dose of 1 ml per 10 kg of animal weight (15 mg of the active substance per 1 kg of body weight). For animals with renal insufficiency, it is recommended to accurately adjust the dose of the drug. Before use, the contents of the vial are thoroughly shaken until a homogeneous suspension is obtained. If necessary, the drug can be re-administered after 48 hours. Only dry sterile syringes and needles are used to administer the amoxicillin suspension. If the administered dose of the drug exceeds 20 ml, it is recommended to administer it in several injections at different points. It is recommended to massage the injection site lightly after administering amoxicillin 15% LA.

SIDE EFFECTS

Allergic reactions to amoxicillin are possible in animals, but they quickly disappear after discontinuing the drug. Intoxication due to overdose is virtually impossible. If allergic reactions occur, it is advisable to administer corticosteroids and adrenaline to animals.

CONTRAINDICATIONS

Hypersensitivity to amoxicillin and other penicillins. Do not administer intravenously. Do not administer to rabbits, hamsters, guinea pigs or gerbils. Amoxicillin must not be mixed with other drugs in the same syringe, and must not be used simultaneously with bacteriostatic chemotherapeutic agents. The drug should not be prescribed for infections caused by penicillinase-producing bacteria.

SPECIAL INSTRUCTIONS

Slaughter of animals for meat is permitted 14 days after the end of drug administration. Meat from animals that were slaughtered before the end of the specified period can be used to feed fur animals or to produce meat and bone meal. Milk from animals that were administered 15% amoxicillin suspension can be used for food purposes 48 hours after the end of treatment. Milk obtained from animals during the period of amoxicillin administration and up to 48 hors after the last administration of the drug is used to feed animals.

STORAGE CONDITIONS

With caution (list B). In a dry place, protected from light and out of reach of children, at a temperature of 5 to 20 °C. Shelf life and - 3 years.