🐈 PRINOCATE spot-on 80/8 mg KRKA 🐈 cats 4-8 kg
1 pipette 0.8 ml contains: Imidacloprid 80 mg + Moxidectin 8 mg
🚑 For use in cats affected by or at risk of mixed parasitic infections:
🔹 Ctenocephalides felis
🔹 Otodectes cynotis
🔹 Control and prevention of flea infestations
🔹 Control of ear mite invasions
🔹 Control of Notoedres cati mange
🔹 Control of lungworms Eucoleus aerophilus syn. Capillaria aerophila (adults), Prevention of lungworm infestation (L3/L4 larvae)
🔹 Aelurostrongylus abstrusus
🔹 Control of lungworm Aelurostrongylus abstrusus (adults) 4'b
🔹 Control of eyeworm Thelazia callipaeda (adults)
🔹 Prevention of heartworm infestation (L3 and L4 larvae Dirofilaria immitis)
🔹 Control of gastrointestinal roundworm infestation (L4 larvae, immature and mature adults Toxocara cati and Ancylostoma tubaeforme)
🔹 The product can be used as part of a combined treatment for flea allergy dermatitis (FAD).
🔹 For use in ferrets affected by, or at risk of, mixed parasitic infections:
felis (larvae L3 and L4)
🔹 Control and prevention of flea infestations (Ctenocephalides Prevention of heartworm invasion Dirofilaria immitis)
🟢 DOSAGE AND METHOD OF ADMINISTRATION:
For external use only (spot-on administration).

To prevent licking, the product should be applied topically to the skin, limiting the area of ​​application to the neck and base of the skull.

✅ Dosage regimen for cats: minimum recommended dose is 0.1 ml of product/kg body weight
🔹 Control and prevention of flea infestations (Ctenocephalides felis):
A single application of the product prevents flea invasion for the next 4 weeks. The pupae in the environment may develop within 6 weeks of starting treatment, or even later, depending on climatic conditions. It may therefore be necessary to combine treatment with this veterinary medicinal product with a procedure to break the flea life cycle in the environment. This may result in an even more rapid destruction of the flea population in the household. If the product is used as part of a combined treatment for flea allergy dermatitis, it should be administered at monthly intervals. 🔹 Treatment of ear mite infestations (Otodectes cynotis):
The product should be administered once. A follow-up examination by a veterinarian is recommended 30 days after the end of treatment, as repeated treatment may be necessary in some cases. The product should not be administered directly into the ear canal. 🔹 Treatment of feline scabies (Notoedres cati):
The product should be administered once. 🔹 Control of lungworm Eucoleus aerophilus (syn. Capillaria aerophila) (adults):
The product should be administered once.

🔹 Prevention of Aelurostrongylus abstrusus:
The product should be administered monthly.

🔹 Control of Aelurostrongylus abstrusus:
The product should be administered monthly for three consecutive months.

🔹 Control of eyeworm Thelazia callipaeda (adults):
The product should be administered once.

🔹 Prevention of heartworm (Dirofilaria immitis):
Cats living in areas endemic for heartworm (Dirofilariosis) or those that have travelled to such areas may be attacked by adult forms of these parasites. Therefore, before administering the product, consider following the advice given in the section
​⚠ SPECIAL WARNINGS:
For the prevention of heartworm disease, the product must be applied at regular monthly intervals during the time of year when mosquitoes (the intermediate hosts that carry the larvae of this worm) are present. The product can be applied throughout the year or at least one month before the first expected appearance of mosquitoes. Treatment should be continued at regular monthly intervals until one month has passed since the last exposure to mosquito bites. To establish a consistent treatment regimen, it is recommended to designate the same day of each month as the day of administration of the product. When replacing another heartworm preventive product as part of a preventive programme, the first application of this product must be within 1 month of the last dose of the previous product.

In areas not endemic for heartworm disease, cats should not be at risk from these parasites. Therefore, this product can be used in cats without any special precautions.
🔹 Control of roundworm and hookworm infections (Toxocara cati and Ancylostoma tubaeforme): USA.

In areas endemic for heartworm, monthly application of the product can significantly reduce the risk of reinfestation caused by both roundworm and hookworm. In areas not endemic for heartworm 

heartworms, the product can be used as part of a seasonal preventive program against fleas and gastrointestinal worms.

🟢 RECOMMENDATIONS FOR CORRECT ADMINISTRATION
Method of administration:
1. Remove the pipette from the packaging. Holding the pipette in a vertical position, twist and remove the tip.

2. Turn the tip over and place the other end back on the pipette. Press and twist the tip to pierce the seal, then remove the tip from the pipette.

3. Part the fur on the animal's neck, at the base of the skull, so that the exposed skin is visible. Place the tip of the pipette on the skin and firmly squeeze the pipette several times to completely squeeze its contents directly onto the skin in one place. Avoid contact of the product with the fingers.
Applying the product at the base of the skull will minimize the possibility of the animal licking the product. The product should only be applied to intact skin.
⚠ CONTRAINDICATIONS:
Do not use in kittens under 9 weeks of age.
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
For ferrets: Do not use the veterinary medicinal product for large cats (0.8 ml) or for dogs (no dose).
For dogs, use an appropriate veterinary medicinal product containing 100 mg/ml imidacloprid and 25 mg/ml moxidectin. Do not use in canaries.

⚠ SIDE EFFECTS:
Use of the product may cause transient symptoms of itching in cats. In rare cases, greasy fur, erythema and vomiting may occur. These symptoms disappear spontaneously, without additional treatment. In sporadic cases, the product may cause local allergic reactions. If the animal licks the application site, in very rare cases, symptoms from the nervous system (mostly transient) may occur, such as ataxia, generalized tremors, ocular symptoms (dilated pupils, weakly expressed pupillary reflex, nystagmus), respiratory disorders, excessive salivation and vomiting.

The product has a bitter taste. In some cases, if the animal licks the application site immediately after the procedure, excessive salivation may occur. This phenomenon is not a symptom of poisoning and disappears spontaneously within a few minutes, without additional procedures. Correct application of the product minimizes the possibility of licking the application site.

In very rare cases, the product may cause a local reaction at the application site, manifested by temporary changes in behavior, such as lethargy, anxiety, lack of appetite.

In the event of accidental ingestion of the product, symptomatic treatment should be initiated. There is no specific antidote. Administration of activated charcoal may be beneficial.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 treated animals displaying adverse reaction(s)
- common (more than 1 but less than 10 in 100 animals treated)
- uncommon (more than 1 but less than 10 in 1000 animals treated)
- rare (more than 1 but less than 10 in 10,000 animals treated)
- very rare (less than 1 in 10,000 animals treated, including isolated reports).

If you notice any serious symptoms or other symptoms not mentioned in the package leaflet, please inform your veterinarian.

⚠ SPECIAL STORAGE PRECAUTIONS:
Keep out of the sight and reach of children.
Store in the original package in order to protect from light and moisture.

There are no special temperature requirements for storing the medicinal product.
Do not use this veterinary medicinal product after the expiry date which is stated on the label and on the carton after EXP. The expiry date refers to the last day of that month
⚠ SPECIAL WARNINGS:
Special warnings for each target species:
The efficacy of the product has not been tested in ferrets weighing more than 2 kg and therefore the duration of action in these animals may be shorter.
Short-term contact of the animal with water, one or two times between monthly applications of the product does not significantly reduce the efficacy of the product. However, frequent shampooing or immersion of the animal in water after application of the product may significantly reduce the efficacy of the product.

Frequent, repeated use of products from any group of antiparasitic products may lead to the development of parasite resistance to products belonging to that group. Therefore, the use of the product should be based on an individual assessment of each case and on local epidemiological data on the susceptibility of the target parasite species in order to limit the possibility of selecting for resistance.

The use of the product should be based on a confirmed diagnosis of mixed infections (or 

n case of their occurrence, in case of prevention) at the same time (see also section INDICATIONS FOR THERAPY and DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATION).

Special precautions for use in animals:

Use in cats weighing less than 1 kg and ferrets weighing less than 0.8 kg should be based on a benefit-risk assessment of the product. Due to the limited experience with the use of this product in sick and debilitated animals, its use in such individuals should be based on a benefit-risk assessment of the product.

Care should be taken to avoid that the contents of the pipette or the product from the application site come into contact with the eyes or mouth of the treated animal or animals in contact with it. Animals to which the product has recently been applied should not be allowed to groom each other (lick each other). Accidental ingestion (licking) by dogs such as Collies or Old English Sheepdogs and related breeds and their crossbreeds should be avoided.

It is recommended that cats and ferrets living in or travelling to areas where the heartworm (Dirofilariosis) is endemic should be treated monthly to protect them from heartworm infestation.

Due to the limited possibility of accurately diagnosing heartworm infestation, it is recommended that every cat or ferret over 6 months of age be tested for it before starting preventive treatment, as the use of the product in a cat or ferret carrying adult heartworm may cause serious adverse effects, including death. If an adult heartworm infestation is diagnosed, it should be treated in accordance with current scientific knowledge.

In some cats, Notoedres cati infestation may be severe. In such severe cases, concomitant supportive treatment is necessary as the sole therapy with the product may not be sufficient to prevent the death of the animal. Imidacloprid is toxic to birds, especially canaries.

Special precautions for persons administering the veterinary medicinal product to animals:
To prevent children from accessing the pipettes, keep the pipettes in the original packaging until they are used and dispose of used pipettes immediately.

Do not ingest. In the event of accidental ingestion, seek medical advice immediately and show the package leaflet or the packaging to the physician.

People with known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin should use the product with particular caution. In very rare cases, the product may cause skin sensitisation or transient skin reactions (e.g. numbness, irritation or a burning/tingling sensation).
In very rare cases, the product may cause respiratory irritation in allergic individuals.
In the event of accidental contact with the eyes, rinse them thoroughly with water. Avoid contact of the product with skin, eyes and mouth.

In the event of accidental spillage onto skin, wash off immediately with soap and water.
Wash hands thoroughly after application.
If skin or eye irritation persists, seek medical advice immediately and show the package leaflet or packaging to the physician. Do not eat, drink or smoke while applying the product.

Avoid touching treated animals, especially children, until the application site has dried. For this purpose, it is recommended to administer the product to the animal in the evening. Recently treated animals should not sleep in the same bed with their owners, especially with children.
The solvent in the product may stain or damage some materials, including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before allowing it to come into contact with such materials.

Pregnancy and lactation:
The safety of this veterinary medicinal product has not been assessed during pregnancy and lactation.
Laboratory studies using both imidacloprid and moxidectin in rats and rabbits have not produced any evidence of teratogenic, embryotoxic or maternotoxic effects. The product should only be used based on a benefit-risk assessment by a veterinarian.

Interactions with other medicinal products or other forms of interaction:
At the time of administration of the veterinary medicinal product to the treated animal, no other antiparasitic products from the macrocyclic lactone group should be used.

No interactions have been observed between the veterinary medicinal product and the most commonly used veterinary medicinal products, 

or during routine procedures.

Overdose (symptoms, emergency procedures, antidotes): Up to 10 times the recommended dose was tolerated by cats, without any evidence of adverse effects or clinical signs.

The combination of imidacloprid and moxidectin was administered to kittens at up to 5 times the recommended dose, every 2 weeks, repeated 6 times, without any serious safety concerns.

Transient dilated pupils, excessive salivation, vomiting and transient tachypnea were observed.

After accidental ingestion or overdose of the product, in very rare cases signs from the nervous system (mostly transient) may appear, such as ataxia, generalized tremor, ocular signs (dilated pupils, weak pupillary reflex, nystagmus), respiratory disorders, excessive salivation and vomiting. The combination of imidacloprid and moxidectin was administered to ferrets at 5 times the recommended dose, at intervals of 2 weeks, repeated 4 times, and no adverse effects or clinical signs were observed.

In the event of accidental ingestion of the product, symptomatic treatment should be initiated. There is no specific antidote. Administration of activated charcoal may be beneficial.

Major pharmaceutical incompatibilities: Not applicable