PROVEKTRA for dogs 4-10 kg, 1 tab
Description
Round biconvex tablets of yellowish-white color with brown specks.

Composition
The drug is designed for dogs with different body weights; each tablet contains active ingredients at the rate of 0.5 mg milbemycin oxime and 5 mg praziquantel per kg of animal body weight.

Excipients: corn starch, lactose monohydrate, microcrystalline cellulose, povidone, magnesium stearate, colloidal silicon dioxide, meat flavoring, yeast powder.

Pharmacological properties
ATCvet QP54, endectocides (QP54AB51, milbemycins)

PROVEKTRA for dogs is a combination drug with a broad spectrum of anthelmintic action. Contains active ingredients: milbemycin oxime and praziquantel.

Milbemycin oxime is a macrocyclic lactone obtained by fermentation of Streptomyces hygroscopicus, type Aureolacrimosus, active against larvae and imago of nematodes parasitizing in the digestive tract of dogs, as well as against larvae of the nematode Dirofilaria immitis (microdirofilaria).

The mechanism of action of milbemycin oxime is to increase the permeability of the membranes of nerve and/or muscle cells of nematodes for chloride ions, which leads to their hyperpolarization. This leads to an irreversible decrease in muscle activity, paralysis and death of parasites.

The maximum concentration of milbemycin oxime in blood plasma is achieved within 2-4 hours, bioavailability is about 80%. It is excreted from the animal body mainly unchanged.

Praziquantel is a derivative of acylated pyrazinoisoquinoline. Praziquantel is active against cestodes and trematodes. By increasing the permeability of parasite cell membranes for calcium ions, it leads to membrane depolarization, muscle contraction and damage to the tegument, which leads to the death of helminths and promotes their elimination from the animal's body.

The maximum concentration of praziquantel in the blood plasma of dogs is achieved after 1-4 hours, bioavailability is about 80%, it is excreted from the body mainly in the form of inactive metabolites in the urine within 48 hours.

PROVEKTRA for dogs, according to its effect on the body, belongs to low-toxic substances (safety class 4), in recommended doses it does not have a sensitizing, embryotoxic or teratogenic effect.

Application
Prevention and treatment of dogs with invasions caused by cestodes - Dipylidium caninum, Taenia spp., Echinococcus spp., Mesocestoides spp.; nematodes – Ancylostoma caninum, Toxocara canis, Toxascaris leonina, Trichuris vulpis, Thelazia callipaeda; Angiostrongylus vasorum (reduces the intensity of infection), Crenosoma vulpis (reduces the intensity of infection), Dirofilaria immitis (prevention of the disease); including combined nematode-cestodal invasions.

The drug can be used to prevent heart dirofilariasis (Dirofilaria immitis).

Dosage
The drug is used for dogs individually once orally with food or forcibly on the root of the tongue in the minimum therapeutic dose: 0.5 mg milbemycin oxime and 5 mg praziquantel per kg of body weight.

Depending on the dog's body weight, the actual dosage is:

Animal's body weight

Dosage

milbemycin oxime

proziquantel

For very small dogs

up to 4 kg

2 mg

20 mg

For small dogs

>4 – 10 kg

5 mg

50 mg

For medium dogs

>10 – 25 kg

12.5 mg

125 mg

For large dogs

>25 – 45 kg

22.5 mg

225 mg

For very large dogs weighing more than 45 kg, the drug can be dosed using an appropriate combination of tablets.

No diet or special feeding regimen is required. Splitting the tablet is not allowed.

For deworming dogs with an invasion caused by Angiostrongylus vasorum, the drug is used for therapeutic purposes four times at intervals of 7 days; for prophylactic purposes - once every 4 weeks at a therapeutic dose.

For deworming dogs with invasion caused by Thelazia callipaeda, the drug is used twice with an interval of 7 days.

For the prevention of dirofilariasis in regions unfavorable for the disease, the drug is used in the spring-summer-autumn period monthly, starting a month before the beginning of the summer of the carriers of the pathogen - mosquitoes and midges, and ending no earlier than a month after the end of their summer. Before deworming, it is necessary to consult a veterinarian to exclude the presence of microdirofilaria in the animal's blood.

The specifics of the drug's action during its first use and cancellation have not been established.

When carrying out deworming, it is necessary to adhere to the recommended periods, but not less than once a quarter. In case of missing the next treatment, the use of the drug is resumed in the same dose and according to the same scheme.

Contraindications
Increased individual sensitivity of animals to the components of the drug!

Expressed violations of the kidney and liver functions!

Do not use the product on puppies under 2 weeks of age and/or weighing less than 0.5 kg!

Do not use on emaciated animals or animals with infectious diseases!

Warning

Deworming of animals during pregnancy and lactation is carried out when necessary and under the supervision of a veterinarian.

When using the drug, strictly adhere to the recommended dosage.

Collie, bobtail, and sheltie dogs are sensitive to all anthelmintic drugs, so the drug should be used when necessary and under the supervision of a veterinarian.

Treatment of dogs with a high number of circulating microdirofilariae (Dirofilaria immitis) can lead to adverse reactions (pale mucous membranes, vomiting, muscle tremors, difficulty breathing, or hypersalivation). These reactions are associated with the release of dead microfilariae proteins and do not indicate direct toxicity of the drug. Treatment of canine microfilaremia (the presence of larvae in the blood) with the drug is not recommended.

In regions with a risk of dirofilariasis or in cases where a dog is imported or exported from a risk area, it is necessary to consult a veterinarian before using the drug to exclude the disease.

All animals kept together must be treated.

For weakened, sick animals or animals with impaired renal and hepatic function, the drug is used only under the supervision of a veterinarian with an assessment of the benefit/risk ratio.

Release form
PET/PE blisters of 1 tablet, packed in cardboard boxes of 2 and 25 pieces.

Storage
The drug is stored in the original manufacturer's packaging separately from food and feed, in a dry place protected from direct sunlight, inaccessible to children and animals at a temperature of 15 to 25 ° C.

Shelf life
3 years.

For use in veterinary medicine!