🐕 GEPAX🐈 Professional liver treatment
🚑 For dogs and cats, it is used for:
🔹 intrahepatic cholestasis, including animals suffering from chronic hepatitis of various etiologies;
🔹 intrahepatic cholestasis in pregnant animals (except cats);
🔹 liver disease in all stages of the disease, including cirrhosis (fibrosis) of the liver;
🔹 poisoning with hepatotoxic substances to increase metabolism;
🔹 treatment of enteritis and hepatitis of various genesis in the acute course of the disease as an antioxidant;
🔹 psychomatic and psychological stress on the nervous system (stress, epilepsy, etc.) as a stabilizing and supporting agent.
🟢 DOSAGE:
The drug is administered intravenously, intramuscularly or subcutaneously.
🔹 Dogs, cats (intramuscularly or subcutaneously) - once a day at a dose of 0.2-0.4 ml (corresponding to 10-20 mg of ademetionine cation) per 1 kg of animal body weight.

The duration of parenteral therapy is 5-10 days.

Before use, the lyophilisate should be dissolved in the added solvent immediately before use. The solution should be clear, without visible particles, from colorless to yellow.

🔹 Dogs, cats (intravenously) - the required dose of ademetionine dissolved in the solvent should be further diluted in 200 ml of 0.9% sodium chloride solution or 5% dextrose (glucose) solution and administered in a slow infusion lasting 40-60 minutes. It is also possible to dilute the required dose of the drug dissolved in the solvent in 20 ml of 0.9% sodium chloride solution and slowly introduce it intravenously.

In the case of subcutaneous and intramuscular administration, it is not necessary to additionally dilute the required dose of the drug dissolved in the solvent.

⚠️ CONTRAINDICATION:
Hypersensitivity to the active substance or to any of the excipients of the drug.

Do not use in animals with symptoms of renal failure.

Do not use in pregnant cats.

⚠️ SIDE EFFECT:
There were no side effects and complications associated with the use of GEPAX.

Symptoms of overdose have not been recorded.
In case of increased individual sensitivity of the animal to the components of the drug and the appearance of side effects, use should be discontinued and symptomatic treatment should be carried out.
🟣 COMPOSITION OF THE MEDICINE:
🔹 Lyophilisate (lyophilized mass with a color from white to yellowish) contains the active substance ademetionine 1,4-butanedisulfonate - 95.0 mg (corresponding to 50 mg of ademetionine cation).
🔹 Solvent (clear, colorless to pale yellow liquid) contains L-lysine, sodium hydroxide and water for injection.
🟢 PHARMACOLOGICAL PROPERTIES:
ATS veterinary classification code: QA16АА02 Other veterinary drugs affecting the digestive system and metabolism. Ademetionine.
Ademetionine (S-adenosyl-L-methionine) is a natural amino acid present in almost all tissues and body fluids. It acts mainly as a coenzyme and methyl group donor in transmethylation reactions, which is an essential metabolic process in animals. Methyl group transfer (transmethylation) is also an essential metabolic process in the formation of the phospholipid bilayer in cell membranes and contributes to membrane fluidity. Ademetionine is able to penetrate the blood-brain barrier.

The transmethylation process involving ademetionine is crucial in the formation of neurotransmitters of the central nervous system, including catecholamines (dopamine, norepinephrine, adrenaline), serotonin, melatonin, histamine.

Ademetionine is also a precursor for the formation of physiological sulfur compounds (cysteine, taurine, glutathione, coenzyme A, etc.) in transsulfuration reactions. Glutathione plays an important role in liver detoxification. Ademetionine increases the level of glutathione in the liver in patients with liver damage. Folic acid (folate) and vitamin B12 are essential co-nutrients in the metabolism and regeneration of ademetionine.

After intravenous administration, the pharmacokinetic profile of ademetionine includes a phase of rapid distribution in tissues and a final elimination phase with a half-life of about 1.5 hours. Absorption after intramuscular administration is almost complete (96%), the maximum concentration in plasma is achieved after about 45 minutes after administration.

STORAGE:
A dark place, inaccessible to children, at a temperature of 5 to 25°C.

The shelf life is 2 years.

⚠️ The drug solution is not subject to storage: after dilution, the drug should be used immediately.
FOR USE IN VETERINARY MEDICINE!