Storage
1 ml of the drug contains active substances: marbofloxacin - 3 mg (mg), clotrimazole - 10 mg (mg), dexamethasone acetate - 1 mg (mg).

Excipients: dimethyl sulfoxide, propylene glycol, castor oil.

Pharmacological properties
ATCvet QS02, veterinary drugs used in otology (QS02CA06 – Corticosteroids (dexamethasone) and antibacterial drugs in combination).

OTODEF is a combined drug with antibacterial, antifungal and anti-inflammatory effects due to the combination of active substances: marbofloxacin, clotrimazole, dexamethasone acetate.

Marbofloxacin is a synthetic, bactericidal antimicrobial substance belonging to the group of fluoroquinolones. It exhibits an antimicrobial effect by inhibiting the activity of the DNA gyrase enzyme, which is an extremely important catalyst for DNA replication in the bacterial cell. Inhibition of DNA gyrase activity leads to functional disorders, blocking of protein biosynthesis in the cell and death of the pathogenic microorganism. The result is a rapid bactericidal effect. Marbofloxacin is effective against a wide range of gram-positive and gram-negative bacteria.

Clotrimazole is a synthetic derivative of imidazole with a pronounced fungicidal effect on dermatophytes (Epidermophytion floccosum, Microsporum spp., Trichophyton spp.), yeast and yeast-like fungi (Candida spp., Cryptococcus neoformans, Toru spp and others), as well as on other pathogenic fungi (Malassezia pachydermatis and others). It suppresses the biosynthesis of ergostyrene and changes the lipid composition of the membrane, which leads to the death of the fungal cell.

Dexamethasone acetate is a synthetic glucocorticosteroid with pronounced anti-inflammatory, anti-allergic and anti-exudative activity, with a rapid onset and short duration of action. Dexamethasone stabilizes cell membranes, reduces the permeability of blood capillaries, exhibits an anti-exudative effect by stabilizing the membranes of lysosomes.

According to the degree of action on the body, Otodef belongs to low-toxic substances (safety class 4), in recommended doses it does not show local irritant and resorptive-toxic effects, it is well tolerated by dogs of different breeds and ages.

Application
Treatment of dogs suffering from acute and chronic otitis externa caused by bacteria and fungi sensitive to the active ingredients of the drug.

Dosage
Only for external use - instillation in the ear. The outer ear must be clean and dry. It is necessary to remove mud, crusts, exudate, etc. from it.

The recommended dose is 2-5 drops of the drug (depending on the size of the animal) in each affected ear once a day. In order for the drug to be evenly distributed in the ear canal, it is necessary to massage the base of the ear.

The duration of treatment is from 7 to 14 days, until the animal fully recovers.

Features of the drug's action during its first use and withdrawal have not been established.

In case of missing the next treatment, the use of the drug is resumed in the same dose and according to the same scheme.

Contraindication
Do not use in animals with known hypersensitivity to the components of the drug!

Do not use in animals with perforation of the tympanic membrane!

Reservation
It is not recommended for pregnant and lactating animals.

Before use, the bottle with the drug is thoroughly shaken.

The drug must be used at room temperature (that is, do not administer a cold drug).

When using the drug, strictly follow the recommended dosage.

Release form
Polymer bottles of 10 ml, individually packed in cardboard boxes.

Storage
The drug is stored in the manufacturer's original packaging, separately from food and feed, in a dry place, protected from direct sunlight, inaccessible to children and animals, at temperatures from 5 °C to 30 °C.

The shelf life is 2 years. After opening the bottle - 3 months.

For use in veterinary medicine!