"🐕 VETOFLOX 10 ml🐈 Eye and ear drops 1 ml: OFLOXACIN 3 mg 🚑 Treatment of dogs, cats, small ornamental animals (ornamental rabbits, hamsters, rats, mice, marmosets, parrots, canaries) in acute and chronic inflammation of the eyes and ears caused by bacterial, chemical or traumatic exposure: conjunctivitis eyelid inflammation inflammation of the cornea and conjunctiva inflammation of the iris inflammation of the ciliary body inflammation of the lacrimal sac keratitis corneal erosion CHLAMYDIA EYE INFECTION eye diseases after injuries, ingestion of foreign bodies or aggressive compounds, in the pre- and postoperative period, as well as treatment of otitis externa and otitis media, in particular otitis media caused by external interference. 🟢 DOSAGE AND ADMINISTRATION: In the presence of significant purulent or mucopurulent discharge, preliminary hygiene procedures for the eyes or ears should be performed, and then the drug should be instilled. Treatment should continue until symptoms disappear and for an additional 2-3 days. The course of treatment until complete recovery is 5-10 days. Do not touch the tip of the dropper to any surface to avoid contamination of the contents of the vial. 🔹 For eye treatment: the drug is instilled into the conjunctival sac 1-2 drops every 2-4 hours for the first 2 days, then - 4 times a day, in the case of CHLAMYDIA infections - 5 times a day. 🔹 In the treatment of ear diseases: the drug is instilled into the ear canal in the amount of 1-4 drops (depending on the animal's body weight) 2-4 times a day until the symptoms of inflammation completely disappear. ⚠️CONTRAINDICATIONS:⚠️ Hypersensitivity to drug components (including history of hypersensitivity). Do not use topically with tetracyclines, macrolides, lincosamides, chloramphenicol. During treatment with ofloxacin, excessive exposure to sunlight or ultraviolet radiation should be avoided. Do not use in case of viral and fungal infections of the eyes and ears. Do not administer to horses. Do not administer in combination with theophylline or with drugs containing magnesium, aluminum and calcium cations, which bind to ofloxacin and prevent its adsorption. Do not use if resistant strains of pathogens are detected. ⚠️WARNINGS: The medicine should be used in accordance with the leaflet included in the package. After instillation into the eyes, local symptoms of discomfort, irritation, itching and tearing may occur, which disappear quickly, and sometimes allergic reactions may occur. Use with caution in animals less than 7 days old and in pregnant animals. 🟢 PHARMACOLOGICAL PROPERTIES: ATC veterinary classification code QJ01 - antibacterial veterinary drugs for systemic administration. QJO1MA01 - Ofloxacin. Ofloxacin is an antibiotic from the fluoroquinolone group that is active against Gram-negative microorganisms, namely: Esherichia coli, Salmonella spp, Proteus spp, Shigella spp, Klebsiella spp, Enterobacter spp, Camphylobacter spp, Yersinia spp, Pseudomonas aeruginosa, Vibrio spp, Aeromonas spp, Haemophilus spp, Serratia spp, Chlamydia spp. Active against some Gram-positive microorganisms, in particular Staphylococcus spp. (including penicillinase-producing and methicillin-resistant strains), Streptococcus spp. Moderately sensitive to ofloxacin are Enterococcus faecalis, Pseudomonas spp. Also sensitive to the drug are: Brucella spp. The mechanism of action of ofloxacin is to inhibit bacterial DNA gyrase (topoisomerase II), which stops the process of spiralization and DNA synthesis. A significant advantage of the drug compared to other topical antibiotics is its high permeability to the cornea and anterior chamber of the eye. Among all fluoroquinolones, ofloxacin has the best ability to penetrate the cornea and anterior chamber of the eye, its effective concentration in the tear film remains even 4 hours (240 minutes) after administration, and its MIC90 is above 2 μg/ml. Systemic reabsorption after topical administration into the conjunctival sac is insignificant and has no clinical significance. Instillation of ofloxacin into the ear with an intact eardrum is accompanied by minimal absorption in the middle ear. However, the absorption of ofloxacin increases in cases of perforation of the tympanic membrane. After instillation of ofloxacin in adult animals with tympanic membrane perforation, the maximum serum concentration is 10 ng/ml. After topical administration, therapeutic concentrations of ofloxacin are achieved in the eye tissues within 30-60 minutes. After 10 days of administration of the drug in therapeutic doses, the concentration of ofloxacin in blood serum was 1000 times lower than the standard concentration after oral administration. 🟡STORAGE: Store in a dry, dark place out of reach of children and animals, away from food and feed, at a temperature of 5 to 25°C. 🟡DURABILITY: 3 years. After first withdrawal from the vial, the medicine should be used within 30 days. For use in veterinary medicine!