Composition
1 tablet (0.5 g) contains the active ingredients:

pyrantel pamoate (embonate) - 144 mg;
praziquantel - 50 mg.
Excipients: powdered sugar, starch, calcium carbonate.

Description
Flat-cylindrical tablets with a notch, uncoated, yellow, odorless.

Pharmacological properties
TCvet QP52, veterinary anthelmintic drugs (QP52AA01, praziquantel; QP52AF02, pyrantel)

The spectrum of anthelmintic action of the drug Wormicil is based on the pharmacological action of the components of the drug - pyrantel pamoate and praziquantel.

Pyrantel pamoate (embonate) is active against nematodes (round helminths), acts on their cholinergic receptors, causing irreversible spastic paralysis. Dead nematodes are excreted from the animal's body by peristaltic movements of the intestine. However, pyrantel is not active against migratory larval stages of helminths.

In the mammalian body, pyrantel is poorly absorbed in the digestive tract and after oral administration at a dose of 10 mg / kg of body weight, its concentration in the blood plasma is 0.005-0.13 μg / ml after 1-3 hours. Pyrantel absorbed into the circulatory system is partially metabolized in the liver to N-methyl-1,3-propanediamine.

Praziquantel is active against cestodes (tapeworms), is quickly absorbed by the entire surface of the parasites and is evenly distributed throughout the body. Praziquantel increases the permeability of membranes for calcium ions, causes an increase in muscle activity, which is changed by its contraction and spastic paralysis, causes the destruction of the outer cuticle in adult forms of cestodes. In some cases, tapeworms are completely digested by digestive enzymes and are not found in feces.

In mammals, praziquantel is rapidly absorbed in the digestive tract. Its highest concentration in blood plasma is achieved 1-2 hours after administration, it is rapidly metabolized and excreted up to 80% as metabolites by the kidneys within 4 days, with 90% excreted in the first 24 hours.

Indications for use
Deworming of dogs and cats with nematodoses (Toxocara canis, Toxocara cati, Toxascaris leonina, Ancylostoma spp., Uncinaria spp., Trichuris spp.) and cestodoses (Dipylidium caninum, Echinococcus multilocularis, Taenia spp., Mesocestoides spp.).

Method of administration and dosage
Orally, tablets are given to the animal directly on the root of the tongue or crushed with food in doses:

Animals

Body weight, kg

Dose of the drug, tablets

Puppies and kittens

0.5-2.0

¼

Cats and small breed dogs

2-5

½

Small breed dogs

5-10

1

Medium breed dogs

10-20

2

20-30

3

Large breed dogs

30-40

4

40-50

5

The recommended dose of the drug is 1 tablet per 10 kg of body weight of the animal, once, without observing a hunger diet.

Deworming of animals is carried out quarterly. It is also recommended to carry out preventive treatments 2-4 weeks before the expected mating date.

Deworming of kittens and puppies can be carried out from the age of 30 days.

Contraindications
Hypersensitivity to the components of the drug.

The drug should not be used by sick and emaciated animals, animals with liver diseases.

Caution
Do not use simultaneously with other antiparasitic drugs.

Production form
Blisters of 10 tablets, cardboard boxes of 2 blisters.

Polyethylene jars with lids of 20, 50 and 100 tablets.

Storage conditions
Store in the original packaging separately from food and feed at a temperature of 2 to 30 ° C and a relative humidity of no more than 75%.

Shelf life
2 years.